PIçO - AN OVERVIEW

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The operate of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which plays a very important regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and influences most cancers mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 can also